Methylated Sept9 Gene is a
Sensitive Biomarker for all Stages of
Colorectal Cancer

Lele Song; Yuemin Li

Abstract

Methylated Sept9 Gene is a Sensitive Biomarker for all Stages of Colorectal Cancer

The SEPT9 gene methylation assay has been proved to be a reliable assay for CRC detection by many studies. Due to the highly sensitive properties of the assay, analysis of quantitative data is crucial for qualitative interpretation of the test results. However, different analysis methods used currently in data interpretation led to variation in test sensitivity and may affect the test effectiveness in CRC detection. Here we review the methods used in data interpretation in major clinical trials performed so far, and provide our recommendations for data interpretation in future practice.

Author(s):

Lele Song, Yuemin Li

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