Colorectal Cancer: Open Access

Possibility Of Employ The Micronucleus Test For The Diagnosis Of The Doubt Cases In The Screening For The Determination Of Breast Cancer

The aim of this study is to check the possibility to use the test with micronuclei in saliva, for cases of doubts,(BIRADS 3), detected in screening for breast cancer. It is been executed a bibliographic search on Pub Med, for articles published from Jan 1, 2000, to Dec 31, 2016,for the keywords : "micronuclei in exfoliated buccal cells in breast cancer “.The keywords are used in the research in free text, and  with cross-referencing method application. Are also executed preliminary tests, not statistically evaluable for low numbers of patients,(seven for both groups), to evaluate the difference, of the score concerning the presence of micronuclei in  BIRADS 3 ,versus  BIRADS2 Five studies show  that in buccal cells, in breast cancer, the amount of  MN are  significantly higher than compared to benign cases as in  six studies  for the detection of micronuclei in needle aspiration in ductal carcinoma ,. Contrasting results are for MN in peripheral blood lymphocytes. Experimentally, in three patients, group  BIRADS 3, was shown to have micronuclei, while no positive findings were found in none of  BIRADS 2 . The references show as the micronuclei scoring can be used as a biomarker on fine-needle aspiration cytology smears of breast cancer,  while the tests in peripheral blood lymphocytes have known reproducibility problems.  Also the bibliography show,in  breast  cancer, an increase of MN in  exfoliated buccal mucosa as well our preliminary cells test, It May be interesting to apply the MN scoring in cases of doubt, according to functional BI-RADS category 3 (probably benign), and which are sent to a successive control.

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Author(s): Menicagli Roberto

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